Updated standings in 1981 Season Replay.
Tigers, Angels, Cardinals, Dodgers lead their respective divisions in the early season.
American League
| American League East | Wins | Loses | American League West | Wins | Loses |
| Detroit Tigers | 8 | 1 | California Angels | 7 | 4 |
| Milwaukee Brewers | 5 | 2 | Oakland A’s | 7 | 5 |
| Boston Red Sox | 5 | 3 | Seattle Mariners | 5 | 5 |
| Baltimore Orioles | 4 | 4 | Chicago White Sox | 3 | 4 |
| New York Yankees | 4 | 4 | Kansas City Royals | 3 | 4 |
| Cleveland Indians | 3 | 4 | Texas Rangers | 3 | 5 |
| Cleveland Indians | 3 | 4 | Minnesota Twins | 2 | 7 |
National League
| National League East | Wins | Loses | National League West | Wins | Loses |
| St. Louis Cardinals | 8 | 0 | Los Angeles Dodgers | 7 | 2 |
| Philadelphia Phillies | 6 | 3 | San Francisco Giants | 6 | 4 |
| Montreal Expos | 5 | 4 | San Diego Padres | 5 | 3 |
| Chicago Cubs | 4 | 5 | Houston Astros | 5 | 4 |
| Pittsburgh Pirates | 2 | 7 | Cincinnati Reds | 3 | 7 |
| New York Mets | 2 | 7 | Atlanta Braves | 2 | 7 |